Tamoxifen Undergoes Optimization Essay -- Medical Drug

Tamoxifen Undergoes OptimizationAbstractComputer programs worry GaussView and Gaussian 03W are some of the advanced toolsthat bear be utilize by scientists to design and optimize new intentional drug. Using the ask sametools as scientists today, I am going to take a known drug, Tamoxifen, and create few analogssimilar to its structure. Before I scum bag create some analogs in GaussView, I am going to theatre of operations andexamine the structure of Tamoxifen to understand the chemistry that involves in this structure.For example, the bonds mingled with molecules and the interactions between the drug and estrogenreceptor complex site. After I design an analog of Tamoxifen, I will then use the Gaussian 03Wprogram to optimize the analog. As for the last step in ascertain if an analog is a goodcandidate for a new designed drug, I am going to use a special computing machine program calledOpenEye Software to help me make that prediction.Introductiontitty pubic louse is the most common type of malignant neoplastic disease known among women in the US. It isthe second-leading evidence of cancer-related deaths. More than 180,000 women are diagnosed withbreast cancer each family. In 2006, disclose of all of these women, 40,000 died. Although breast cancermainly affects women, data shows that men can also be affected as well each year more than1,000 men are diagnosed with breast cancer 3. This information shows that cancer can affectanyone regardless of an individuals gender, ethnicity, etc. It is pregnant that everyone knows almost breast cancer and helps friends or family members with breast cancer to befall way todiagnose it. In nowadays, scientists are learning more about cancer and are exploring new waysto prevent, detect, diagnose, and treat this deadly disease 1.... ...c., 1997.3. Corey, E. J., Barbara Czako, and Laszlo Kurti. Molecules and medicine. New Jersey JohnWiley &Sons, Inc., 2007.4. Jordan, V., ed. Long-Term Tamoxifen Treatment for Breast Cancer. Wisconsin TheUniversity of Wisconsin Press, 1994.5. Oxford University Press. Figure 18.44 Tamoxifen. Online Resource Centre. 29 Jul. 2008.tamoxifen.jpg.6. Wikipedia. Tamoxifen. Wikipedia. 29 Jul. 2008..7. Wiseman, Helen. Tamoxifen-Molecular Basis of Use in Cancer Treatment and Prevention.England John Wiley &Sons Ltd, 1994.8. Nolte, RT. Crystal structure of Estrogen link Reecptor-3 (ERR-gamma) ligand bindingdomaind with tamoxifen analog GSK5182. Protein Data Bank. 29 Jul. 2008..